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The Hemp Entourage Effect

Updated: Aug 5, 2019



In the world of Hemp CBD today, many companies stray from the “broad spectrum” or “full spectrum” products and settle with Isolate CBD. While this may seem logical from a sales standpoint (Being that almost all 50 states accept sales of Isolate CBD) and consumers might feel some beneficial effect from it, these companies are really missing out on the innumerable benefits numerous cannabinoids and terpenes provide. By incorporating the vast array of plant cannabinoids and terpinoids (terpenes), they work together synergistically to provide a more powerful and medicinal effect. This is the entourage effect.


Why the Entourage Effect is so Important


Let’s start with the endocannabinoid system. This system’s primary function is to keep your body in homeostasis. To do that, there are an enormous number of receptors throughout your body and inside your brain that stimulate or antagonize functions. There is a list of different receptors that make up the endocannabinoid system, but the main receptors to note are the CB1 and CB2 receptors. Not only does each receptor has a specific form and function that affects the body, each receptor connects with different sets of cannabinoids. For example, THC has more of a connection compatibility with CB1 receptors and CBD has more of a connection compatibility with CB2 receptors.


CBG, the 3rd most prominent cannabinoid in Cannabis and the 2nd most common in Hemp, is one of the only cannabinoids that work with receptors outside of the endocannabinoid system.

Modern science has proven that every action the human body makes takes a wide variety of parts, receptors, and synapses to perform in concert. Therefore, since each receptor connects with different cannabinoids, even rudimentary conclusions would surmise that utilizing a single cannabinoid would not provide the desired effect; that it would take an “entourage” of cannabinoids to properly perform the specified application.


This is where PhD panelists Jake Black (Treehouse Biotech), Dr. Priyanka Sharma (Kazmira), and Eric Miller (Extract Labs) set their roots. Their companies extract hemp biomass to create isolate cannabinoids and broad/full spectrum cannabinoids. The beauty of isolating the cannabinoids in this area is in formulation. With the isolated molecules, they can produce a mixture of whatever percentage they want of each cannabinoid to fulfill the target dosages.


It’s Not Just Cannabinoids Though


Each cannabinoid has a remarkable swath of benefits, which have been thoroughly detailed by reputable sites and research studies. However, cannabinoids on their own can be less efficacious for targeted application. Have you ever wondered why a strain like Jack Herrer will give you that uplifting head high and Purple strains like Granddaddy Purple (GDP) will have you couch locked for hours? Both strains have roughly the same amount of THC to CBD ratio, so what gives?


Even if you didn’t look at those strains, I’m sure you could differentiate them based on their smell. Up until the past decade or so, we have known how to classify what each strain does based off its smell. Now we know that it is the molecules that give off that smell that induce those specific responses. These molecules are terpenes.


Extensive research has been done on terpenes and their interactions with the body and mind. Like Cannabis and Hemp, terpenes have been utilized since the dawn of time, we just have known them by a different name – essential oils. Cannabis has over 300 known terpenes, and each can be found in at least 1 of more than 10,000 different plant species.


What research and studies have found is how these terpenes can carry these cannabinoids to do specific applications. Terpenes are much smaller than cannabinoids and can penetrate the blood-brain barrier much quicker. Cannabinoids hop on for the ride to give you a more potent effect. On top of that, terpenes interact with endocannabinoid receptors to provide a plethora of benefits too!


This is exactly why broad or full spectrum products work so much better. Isolates can only do so much. Hence why pharma knockoffs of THC (Drobinol and Marinol) were not very effective.


Uniting Herbal Powerhouses


Now that cannabinoids like CBD are widely known for their medicinal benefits, companies are combining these products with other herbs to create phenomenal products. Dr. Janelle Kim (JBK Wellness) utilizes her extensive knowledge of eastern medicine to formulate topical products with CBD. She feels that by combining all the parts of the herbs used, not just the isolated terpenes, the products provide a much larger range of benefits.


It’s Just Synergistically Sound


Products with isolate cannabinoids are just not very effective. Now with the technology we have today and the brilliance of the formulators like our panelists, we can create excellent formulations of whatever percentage desired. By providing the synergy of multiple cannabinoids and terpenes, your body can truly receive the full array of benefits.



See the Panel Video at the link below!



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