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The Hemp Entourage Effect

Updated: Aug 5, 2019



In the world of Hemp CBD today, many companies stray from the “broad spectrum” or “full spectrum” products and settle with Isolate CBD. While this may seem logical from a sales standpoint (Being that almost all 50 states accept sales of Isolate CBD) and consumers might feel some beneficial effect from it, these companies are really missing out on the innumerable benefits numerous cannabinoids and terpenes provide. By incorporating the vast array of plant cannabinoids and terpinoids (terpenes), they work together synergistically to provide a more powerful and medicinal effect. This is the entourage effect.


Why the Entourage Effect is so Important


Let’s start with the endocannabinoid system. This system’s primary function is to keep your body in homeostasis. To do that, there are an enormous number of receptors throughout your body and inside your brain that stimulate or antagonize functions. There is a list of different receptors that make up the endocannabinoid system, but the main receptors to note are the CB1 and CB2 receptors. Not only does each receptor has a specific form and function that affects the body, each receptor connects with different sets of cannabinoids. For example, THC has more of a connection compatibility with CB1 receptors and CBD has more of a connection compatibility with CB2 receptors.


CBG, the 3rd most prominent cannabinoid in Cannabis and the 2nd most common in Hemp, is one of the only cannabinoids that work with receptors outside of the endocannabinoid system.

Modern science has proven that every action the human body makes takes a wide variety of parts, receptors, and synapses to perform in concert. Therefore, since each receptor connects with different cannabinoids, even rudimentary conclusions would surmise that utilizing a single cannabinoid would not provide the desired effect; that it would take an “entourage” of cannabinoids to properly perform the specified application.


This is where PhD panelists Jake Black (Treehouse Biotech), Dr. Priyanka Sharma (Kazmira), and Eric Miller (Extract Labs) set their roots. Their companies extract hemp biomass to create isolate cannabinoids and broad/full spectrum cannabinoids. The beauty of isolating the cannabinoids in this area is in formulation. With the isolated molecules, they can produce a mixture of whatever percentage they want of each cannabinoid to fulfill the target dosages.


It’s Not Just Cannabinoids Though