Drug Interactions with CBD
Reviewed & Approved by Dr. Jeff Mara
CBD IS PROCESSED IN THE LIVER THROUGH THE CYTOCHROME P450 ENZYME PATHWAY. AT LOW & REGULAR DOSES, THE RISK OF SIGNIFICANT DRUG INTERACTION IS SMALL, HOWEVER THERE IS THE POTENTIAL THAT CBD MAY INCREASE THE SERUM CONCENTRATION OF THE FOLLOWING DRUGS OR CLASSES OF DRUGS.
WE RECOMMEND THAT YOU DISCUSS YOUR USE OF CBD, CANNABIS, OR ANY OTHER HERBAL PRODUCTS WITH YOUR PHYSICIAN.
For Physicians
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Anticoagulants
Medicines that help prevent blood clots.
Drugs in this class:
Coumadin (Warfarin)
Rivaroxaban (Xarelto)
Beta Blockers
Medicines that decreases the activity of the heart by blocking the action of hormones like adrenaline.
Drugs in this class:
Atenolol (Tenormin)
Bisoprolol (Cardicor, Emcor)
Metoprolol (Betaloc, Lopresor)
Macrolides
An antibiotic that inhibits the growth of bacteria and are often prescribed to treat rather common bacterial infections.
Drugs in this class:
Azithromycin (Zithromax)
Clarithromycin (Biaxin)
Erythromycin
Calcium Channel Blockers
Medicines used to lower blood pressure by slowing the movement of calcium into the cells of the heart and blood vessel walls.
Drugs in this class:
Amlodipine (Norvasc)
Felodipine (Plendil)
Diltiazem (Cardizem)
Tri-Cyclic Antidepressants
Medicine that increases levels of norepinephrine and serotonin, two neurotransmitters, and block the action of acetylcholine.
Drugs in this class:
Amitriptyline (Elavil)
Nortriptyline (Pamelor)
Doxepin (Sinequan)
SSRI's (Selective Seratonin Reuptake Inhibitors)
Medicine that blocks the reabsorption (reuptake) of serotonin in the brain, making more serotonin available.
Drugs in this class:
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
Paroxetine (Paxil)
Sertraline (Zoloft)
Anti-Retrovirals
Medicines that treat HIV.
Drugs in this class:
Abacavir (Ziagen)
Lamivuadine (Epivir)
Zidovudine (Retrovir)
Antihistamines
Medicines that reduce or block histamines to stop allergy symptoms.
Drugs in this class:
Cetirizine (Zyrtec)
Diphenhydramine (Benadryl)
Fexofenadine (Allegra)
Loratadine (Claritin, Alavert)
Anti-Psychotics
Medicines that are used as a short-term treatment for bipolar disorder to control psychotic symptoms such as hallucinations, delusions, or mania symptoms.
Drugs in this class:
Aripiprazole (Abilify)
Clozapine (Clozaril)
Olanzapine (Zyprexa)
Quetiapine (Seroquel)
Risperidone (Risperdal)
Benzodiazapines
Medicines primarily used for treating anxiety, but they also are effective in treating several other conditions.
Drugs in this class:
Alprazolam (Xanax)
Clonazepam (Klonopin)
Diazepam (Valium)
Lorazapem (Ativan)
Temazepam (Restoril)
Opioids
Medicines used to reduce severe pain.
Drugs in this class:
Oxycodone (OxyContin)
Hyrocodone (Vicodin)
Fentanyl
Morphine
Cyclosporine
Medicines used to prevent organ rejection in people who have received a liver, kidney, or heart transplant.
Drugs in this class:
Neoral
Sandimmune
Gengraf
Sildenafil
Medicines used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.
Drugs in this class:
Viagra
Revatio
"Some" Statins
Medicines often prescribed by doctors to help lower cholesterol levels in the blood to help prevent heart attacks and stroke.
Drugs affected in this class:
Atorvastatin (Lipitor)
Symvastatin (Zocor)
Drugs NOT Affected in this class:
Pravastatin (Pravachol)
Rosuvastatin (Crestor)
References
AN UPDATE ON SAFETY AND SIDE EFFECTS OF CANNABIDIOL: A REVIEW OF CLINICAL DATA & RELEVANT ANIMAL STUDIES
CANNABIDIOL: FROM AN INACTIVE CANNABINOID TO A DRUG WITH A WIDE SPECTRUM OF ACTION
SAFETY AND SIDE EFFECTS OF CANNABIDIOL, A CANNABIS SATIVA CONSTITUENT
CANNABIDIOL IN ANXIETY & SLEEP: A LARGE CASE SERIES
CANNABIDIOL AS A POTENTIAL TREATMENT FOR ANXIETY DISORDERS
EFFECTIVENESS OF CANNABIDIOL OIL FOR PEDIATRIC ANXIETY AND INSOMNIA AS PART OF PTSD: A CASE REPORT
TRANSDERMAL CANNABIDIOL REDUCES INFLAMMATION & PAIN RELATED BEHAVIORS IN A RAT MODEL OF ARTHRITIS