Drug Interactions with CBD

Reviewed & Approved by Dr. Jeff Mara

CBD IS PROCESSED IN THE LIVER THROUGH THE CYTOCHROME P450 ENZYME PATHWAY. AT LOW & REGULAR DOSES, THE RISK OF SIGNIFICANT DRUG INTERACTION IS SMALL, HOWEVER THERE IS THE POTENTIAL THAT CBD MAY INCREASE THE SERUM CONCENTRATION OF THE FOLLOWING DRUGS OR CLASSES OF DRUGS.

WE RECOMMEND THAT YOU DISCUSS YOUR USE OF CBD, CANNABIS, OR ANY OTHER HERBAL PRODUCTS WITH YOUR PHYSICIAN.

For Physicians

Click the button below to download the PDF One-Sheet. Research articles are located on page 2 of the PDF. If you would like to recieve a laminated physical sheet, email us at cbdsocietyus@gmail.com 

Anticoagulants

Medicines that help prevent blood clots.

Drugs in this class:

 Coumadin (Warfarin)

Rivaroxaban (Xarelto)

Beta Blockers

Medicines that decreases the activity of the heart by blocking the action of hormones like adrenaline.

Drugs in this class:

Atenolol (Tenormin)

Bisoprolol (Cardicor, Emcor)

Metoprolol (Betaloc, Lopresor)

Macrolides

An antibiotic that inhibits the growth of bacteria and are often prescribed to treat rather common bacterial infections.

Drugs in this class:

Azithromycin (Zithromax)

Clarithromycin (Biaxin)

Erythromycin

Calcium Channel Blockers

Medicines used to lower blood pressure by slowing the movement of calcium into the cells of the heart and blood vessel walls.

Drugs in this class:

Amlodipine (Norvasc)

Felodipine (Plendil)

Diltiazem (Cardizem)

Tri-Cyclic Antidepressants

Medicine that increases levels of norepinephrine and serotonin, two neurotransmitters, and block the action of acetylcholine.

Drugs in this class:

Amitriptyline (Elavil)

Nortriptyline (Pamelor)

Doxepin (Sinequan)

SSRI's (Selective Seratonin Reuptake Inhibitors)

Medicine that blocks the reabsorption (reuptake) of serotonin in the brain, making more serotonin available.

Drugs in this class:

Citalopram (Celexa)

Escitalopram (Lexapro)

Fluoxetine (Prozac)

Paroxetine (Paxil)

Sertraline (Zoloft)

Anti-Retrovirals

Medicines that treat HIV.

Drugs in this class:

Abacavir (Ziagen)

Lamivuadine (Epivir)

Zidovudine (Retrovir)

Antihistamines

Medicines that reduce or block histamines to stop allergy symptoms.

Drugs in this class:

Cetirizine (Zyrtec)

Diphenhydramine (Benadryl)

Fexofenadine (Allegra)

Loratadine (Claritin, Alavert)

Anti-Psychotics

Medicines that are used as a short-term treatment for bipolar disorder to control psychotic symptoms such as hallucinations, delusions, or mania symptoms.

Drugs in this class:

Aripiprazole (Abilify)

Clozapine (Clozaril)

Olanzapine (Zyprexa)

Quetiapine (Seroquel)

Risperidone (Risperdal)

Benzodiazapines

Medicines primarily used for treating anxiety, but they also are effective in treating several other conditions.

Drugs in this class:

Alprazolam (Xanax)

Clonazepam (Klonopin)

Diazepam (Valium)

Lorazapem (Ativan)

Temazepam (Restoril)

Opioids

Medicines used to reduce severe pain.

Drugs in this class:

Oxycodone (OxyContin)

Hyrocodone (Vicodin)

Fentanyl

Morphine

Cyclosporine

Medicines used to prevent organ rejection in people who have received a liver, kidney, or heart transplant.

Drugs in this class:

Neoral

Sandimmune

Gengraf

Sildenafil

Medicines used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.

Drugs in this class:

Viagra

Revatio

"Some" Statins

Medicines often prescribed by doctors to help lower cholesterol levels in the blood to help prevent heart attacks and stroke.

Drugs affected in this class:

Atorvastatin (Lipitor)

Symvastatin (Zocor)

Drugs NOT Affected in this class:

Pravastatin (Pravachol)

Rosuvastatin (Crestor)

References

AN UPDATE ON SAFETY AND SIDE EFFECTS OF CANNABIDIOL: A REVIEW OF CLINICAL DATA & RELEVANT ANIMAL STUDIES​

https://www.ncbi.nlm.nih.gov/pubmed/28861514

CANNABIDIOL: FROM AN INACTIVE CANNABINOID TO A DRUG WITH A WIDE SPECTRUM OF ACTION

https://www.ncbi.nlm.nih.gov/pubmed/18833429

SAFETY AND SIDE EFFECTS OF CANNABIDIOL, A CANNABIS SATIVA CONSTITUENT

https://www.ncbi.nlm.nih.gov/pubmed/22129319

CANNABIDIOL IN ANXIETY & SLEEP: A LARGE CASE SERIES

https://www.ncbi.nlm.nih.gov/pubmed/30624194

CANNABIDIOL AS A POTENTIAL TREATMENT FOR ANXIETY DISORDERS

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/

TRANSDERMAL CANNABIDIOL REDUCES INFLAMMATION & PAIN RELATED BEHAVIORS IN A RAT MODEL OF ARTHRITIS

https://www.ncbi.nlm.nih.gov/pubmed/26517407

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