CBD IS PROCESSED IN THE LIVER THROUGH THE CYTOCHROME P450 ENZYME PATHWAY. AT LOW & REGULAR DOSES, THE RISK OF SIGNIFICANT DRUG INTERACTION IS SMALL, HOWEVER THERE IS THE POTENTIAL THAT CBD MAY INCREASE THE SERUM CONCENTRATION OF THE FOLLOWING DRUGS OR CLASSES OF DRUGS.
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WE RECOMMEND THAT YOU DISCUSS YOUR USE OF CBD, CANNABIS, OR ANY OTHER HERBAL PRODUCTS WITH YOUR PHYSICIAN.
For Physicians
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Anticoagulants
Medicines that help prevent blood clots.
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Drugs in this class:
Coumadin (Warfarin)
Rivaroxaban (Xarelto)
Beta Blockers
Medicines that decreases the activity of the heart by blocking the action of hormones like adrenaline.
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Drugs in this class:
Atenolol (Tenormin)
Bisoprolol (Cardicor, Emcor)
Metoprolol (Betaloc, Lopresor)
Macrolides
An antibiotic that inhibits the growth of bacteria and are often prescribed to treat rather common bacterial infections.
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Drugs in this class:
Azithromycin (Zithromax)
Clarithromycin (Biaxin)
Erythromycin
Calcium Channel Blockers
Medicines used to lower blood pressure by slowing the movement of calcium into the cells of the heart and blood vessel walls.
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Drugs in this class:
Amlodipine (Norvasc)
Felodipine (Plendil)
Diltiazem (Cardizem)
Tri-Cyclic Antidepressants
Medicine that increases levels of norepinephrine and serotonin, two neurotransmitters, and block the action of acetylcholine.
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Drugs in this class:
Amitriptyline (Elavil)
Nortriptyline (Pamelor)
Doxepin (Sinequan)
SSRI's (Selective Seratonin Reuptake Inhibitors)
Medicine that blocks the reabsorption (reuptake) of serotonin in the brain, making more serotonin available.
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Drugs in this class:
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluoxetine (Prozac)
Paroxetine (Paxil)
Sertraline (Zoloft)
Anti-Retrovirals
Medicines that treat HIV.
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Drugs in this class:
Abacavir (Ziagen)
Lamivuadine (Epivir)
Zidovudine (Retrovir)
Antihistamines
Medicines that reduce or block histamines to stop allergy symptoms.
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Drugs in this class:
Cetirizine (Zyrtec)
Diphenhydramine (Benadryl)
Fexofenadine (Allegra)
Loratadine (Claritin, Alavert)
Anti-Psychotics
Medicines that are used as a short-term treatment for bipolar disorder to control psychotic symptoms such as hallucinations, delusions, or mania symptoms.
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Drugs in this class:
Aripiprazole (Abilify)
Clozapine (Clozaril)
Olanzapine (Zyprexa)
Quetiapine (Seroquel)
Risperidone (Risperdal)
Benzodiazapines
Medicines primarily used for treating anxiety, but they also are effective in treating several other conditions.
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Drugs in this class:
Alprazolam (Xanax)
Clonazepam (Klonopin)
Diazepam (Valium)
Lorazapem (Ativan)
Temazepam (Restoril)
Opioids
Medicines used to reduce severe pain.
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Drugs in this class:
Oxycodone (OxyContin)
Hyrocodone (Vicodin)
Fentanyl
Morphine
Cyclosporine
Medicines used to prevent organ rejection in people who have received a liver, kidney, or heart transplant.
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Drugs in this class:
Neoral
Sandimmune
Gengraf
Sildenafil
Medicines used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.
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Drugs in this class:
Viagra
Revatio
"Some" Statins
Medicines often prescribed by doctors to help lower cholesterol levels in the blood to help prevent heart attacks and stroke.
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Drugs affected in this class:
Atorvastatin (Lipitor)
Symvastatin (Zocor)
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Drugs NOT Affected in this class:
Pravastatin (Pravachol)
Rosuvastatin (Crestor)
References
AN UPDATE ON SAFETY AND SIDE EFFECTS OF CANNABIDIOL: A REVIEW OF CLINICAL DATA & RELEVANT ANIMAL STUDIES​